D3669
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D3669
Sigma
3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester)
powder
| Synonym: | Di(N-succinimidyl) 3,3′-dithiodipropionate, Dithiobis(succinimidyl propionate), DTSP, Lomant’s reagent |
| CAS Number: | 57757-57-0 |
| Linear Formula: | C14H16N2O8S2 |
| Molecular Weight: | 404.42 |
| Beilstein Registry Number: | 1518074 |
| EC Number: | 260-931-5 |
| MDL number: | MFCD00042045 |
| PubChem Substance ID: | 24893777 |
Description
| Application | Homobifunctional cross-linking reagent containing a cleavable disulfide linkage. Typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). |
| Caution | Avoid use of reducing agents during coupling reactions. |
| Features and Benefits | The disulfide linkage is cleavable by mild reduction. |
Properties
| form | powder |
| solubility | chloroform: 50 mg/mL |
| DMF: soluble | |
| acetone: soluble | |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
References
| reference | Lomant, A.J. and Fairbanks, G., Chemical probes of extended biological structures: synthesis and properties of the cleavable protein cross-linking reagent [35S]dithiobis(succinimidyl propionate). J. Mol. Biol. 104, 243-261, (1976) Abstract |
| Darder M., et al., Dithiobissuccinimidyl propionate as an anchor for assembling peroxidases at electrodes surfaces and its application in a H2O2 biosensor. Anal. Chem. 71, 5530, (1999) Abstract |
